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Chinmedomics facilitated quality-marker discovery of Sijunzi decoction to treat spleen qi deficiencysyndrome

Qiqi Zhao, Xin Gao, Guangli Yan, Aihua Zhang, Hui Sun, Ying Han, Wenxiu Li, Liang Liu, Xijun Wang

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 335-356 doi: 10.1007/s11684-019-0705-9

Abstract: Sijunzi decoction (SJZD) is a Chinese classical formula to treat spleen qi deficiency syndrome (SQDS)

Keywords： traditional Chinese medicine     Sijunzi decoction     spleen qi deficiency syndrome     Chinmedomics     quality-marker    

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Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 319-323 doi: 10.1007/s11684-017-0553-4

Abstract: Mutations in and lead to deficiency or dysfunction of the two proteins, which could result in venousCoagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreasedThis study demonstrates that the combination of antithrombin deficiency and decreased protein C activity

Keywords： antithrombin deficiency     protein C activity     mutation     variant     venous thromboembolism     anticoagulants    

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Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Frontiers of Medicine   Pages 957-971 doi: 10.1007/s11684-023-0988-8

Abstract: To the best of our knowledge, this study is the first to report DNAH10 deficiency related to PCD

Keywords： DNAH10     mice     motile cilia     mutation     primary ciliary dyskinesia    

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High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome

Heng Fang, Aihua Zhang, Xiaohang Zhou, Jingbo Yu, Qi Song, Xijun Wang

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 651-663 doi: 10.1007/s11684-019-0709-5

Abstract: This study used the established Yang Huang syndrome (YHS) mouse model to evaluate the efficacy of geniposideis a robust combination for deciphering the pathogenesis of the traditional Chinese medicine (TCM) syndrome

Keywords： metabolomics     liquid chromatography-mass spectrometry     metabolites     metabolic pathways    

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Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty

Yue Zhao, Wenjun Long, Caiqi Du, Huanhuan Yang, Shimin Wu, Qin Ning, Xiaoping Luo

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 174-181 doi: 10.1007/s11684-017-0544-5

Abstract:

The relationship between vitamin D deficiency and idiopathic central precocious puberty (ICPP) hasThe ICPP subjects with 25[OH]D deficiency had a higher body mass index (BMI) than the subjects from the

Keywords： idiopathic central precocious puberty     threshold effects     vitamin D status    

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non-inferiority trial of intravenous ferric carboxymaltose versus iron sucrose in patients with iron deficiency

Frontiers of Medicine doi: 10.1007/s11684-023-1001-2

Abstract: Iron deficiency (ID) and ID anemia (IDA) pose significant public health concerns in China.

Keywords： iron deficiency     anemia     intravenous iron     ferric carboxymaltose     iron sucrose     Hb response     early response    

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Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 651-658 doi: 10.1007/s11684-021-0859-0

Abstract: To present the clinical characteristics and the misdiagnosis rate of acute coronary syndrome manifestedcomplaint of throat discomfort, absence of chest pain at onset, and an ultimate diagnosis of acute coronary syndromedyspnea, perspiring, and exertional throat symptoms were significantly associated with acute coronary syndromeThroat discomfort can be the principal manifestation of acute coronary syndrome.throat symptoms, chest tightness, perspiring, and dyspnea were important indicators of acute coronary syndrome

Keywords： acute coronary syndrome (ACS)     throat discomfort (TD)     throat pain     cardiology departments     non-cardiologic    

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Aneurysmal dilatation of the aortic sinuses of Valsalva — beyond Marfan syndrome: a single centre experience

Maryanne Caruana,Mary N. Sheppard,Wei Li

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 419-426 doi: 10.1007/s11684-014-0383-6

Abstract: of Valsalva has been most extensively documented in the setting of aortopathies, particularly Marfan syndromereview, we carried out a literature search on aneurysmal dilatation of the sinuses of Valsalva in Marfan syndromeIn conclusion, there are differences in management of aortic dilatation in Marfan syndrome and congenital

Keywords： sinus of Valsalva aneurysms     Marfan syndrome     aortic dissection    

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Lung transplantation for bronchiolitis obliterans syndrome after allogenic hematopoietic stem cell transplantation

Fei Gao, Jingyu Chen, Dong Wei, Bo Wu, Min Zhou

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 224-228 doi: 10.1007/s11684-017-0538-3

Abstract:

Bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HSCT) is a

Keywords： bronchiolitis obliterans syndrome (BOS)     hematopoietic stem cell transplantation (HSCT)     lung transplantation    

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Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Engineering doi: 10.1016/j.eng.2023.06.007

Abstract: Intestinal homeostasis is maintained by specialized host cells and the gut microbiota. Wnt/β-catenin signaling is essential for gastrointestinal development and homeostasis, and its dysregulation has been implicated in inflammation and colorectal cancer. Axin1 negatively regulates activated Wnt/β-catenin signaling, but little is known regarding its role in regulating host–microbial interactions in health and disease. Here, we aim to demonstrate that intestinal Axin1 determines gut homeostasis and host response to inflammation. Axin1 expression was analyzed in human inflammatory bowel disease datasets. To explore the effects and mechanism of intestinal Axin1 in regulating intestinal homeostasis and colitis, we generated new mouse models with Axin1 conditional knockout in intestinal epithelial cell (IEC; Axin1ΔIEC) and Paneth cell (PC; Axin1ΔPC) to compare with control (Axin1LoxP; LoxP: locus of X-over, P1) mice. We found increased Axin1 expression in the colonic epithelium of human inflammatory bowel disease (IBD). Axin1ΔIEC mice exhibited altered goblet cell spatial distribution, PC morphology, reduced lysozyme expression, and enriched Akkermansia muciniphila (A. muciniphila). The absence of intestinal epithelial and PC Axin1 decreased susceptibility to dextran sulfate sodium-induced colitis in vivo. Axin1ΔIEC and Axin1ΔPC mice became more susceptible to dextran sulfate sodium (DSS)-colitis after cohousing with control mice. Treatment with A. muciniphila reduced DSS-colitis severity. Antibiotic treatment did not change the IEC proliferation in the Axin1Loxp mice. However, the intestinal proliferative cells in Axin1ΔIEC mice with antibiotic treatment were reduced compared with those in Axin1ΔIEC mice without treatment. These data suggest non-colitogenic effects driven by the gut microbiome. In conclusion, we found that the loss of intestinal Axin1 protects against colitis, likely driven by epithelial Axin1 and Axin1-associated A. muciniphila. Our study demonstrates a novel role of Axin1 in mediating intestinal homeostasis and the microbiota. Further mechanistic studies using specific Axin1 mutations elucidating how Axin1 modulates the microbiome and host inflammatory response will provide new therapeutic strategies for human IBD.

Keywords： Axin1     Bacteria     Microbiome inflammation     Inflammatory bowel disease     Immunity     Microbiome     Paneth cells     Akkermansia muciniphila     Wnt    

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Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis

Jian Liu, Weiming Wang

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 333-339 doi: 10.1007/s11684-017-0564-1

Abstract:

Nephrotic syndrome (NS) is one of the most common glomerular diseases with signs of nephrosis, heavy

Keywords： nephrotic syndrome     focal segmental glomerulosclerosis     genetic    

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Cushing’s syndrome during pregnancy caused by adrenal cortical adenoma: a case report and literature

Wei Wang,Fengyi Yuan,Dan Xu

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 380-383 doi: 10.1007/s11684-015-0407-x

Abstract:

Cushing’s syndrome (CS) during pregnancy is a rare condition with significant maternal and fetal

Keywords： Cushing’s syndrome     pregnancy     adrenocortical adenoma    

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Differential diagnosis of cervical nerve compression syndrome of the external intervertebral foramen

WANG Jinwu, NI Weifeng, XU Jianguang, ZHU Haibo, GUO Shangchun, ZENG Bingfang, ZHAO Binghui

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 177-180 doi: 10.1007/s11684-007-0033-3

Abstract: The aim of the present research is to study the mechanism of cervical nerve compression syndrome of themedicine and celecoxib (COX)-2 inhibitor were performed in 20 patients with cervical nerve compression syndromeFifteen cases with cervical nerve compression syndrome of the external intervertebral foramen were healedThe etiology of cervical nerve compression syndrome of the external intervertebral foramen lies in theDiagnostic treatment was propitious to differentiate cervical nerve compression syndrome of the external

Keywords： satisfactory     COX     minimus     operation     compression syndrome    

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Familial amyloid cardiomyopathy masquerading as chronic Guillain-Barre syndrome: things are not always

Die Hu, Ling Liu, Shuguang Yuan, Yuhong Yi, Daoquan Peng

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 293-296 doi: 10.1007/s11684-017-0516-9

Abstract: The patient presented with hypertension, chronic Guillain-Barre syndrome, and sick sinus syndrome.the diagnosis of familial amyloid cardiomyopathy, which was misdiagnosed as chronic Guillain-Barre syndrome

Keywords： transthyretin (TTR) cardiac amyloidosis     sick sinus syndrome     chronic Guillain-Barre syndrome    

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Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns

Jaffar A. Al-Tawfiq,Ali S. Omrani,Ziad A. Memish

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 111-119 doi: 10.1007/s11684-016-0446-y

Abstract:

The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 brought back memoriesof the occurrence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002.

Keywords： coronavirus     MERS     Middle East respiratory syndrome    

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Title Author Date Type Operation

Chinmedomics facilitated quality-marker discovery of Sijunzi decoction to treat spleen qi deficiencysyndrome

Qiqi Zhao, Xin Gao, Guangli Yan, Aihua Zhang, Hui Sun, Ying Han, Wenxiu Li, Liang Liu, Xijun Wang

Journal Article

Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Journal Article

Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Journal Article

High-throughput metabolomics reveals the perturbed metabolic pathways and biomarkers of Yang Huang syndrome

Heng Fang, Aihua Zhang, Xiaohang Zhou, Jingbo Yu, Qi Song, Xijun Wang

Journal Article

Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty

Yue Zhao, Wenjun Long, Caiqi Du, Huanhuan Yang, Shimin Wu, Qin Ning, Xiaoping Luo

Journal Article

non-inferiority trial of intravenous ferric carboxymaltose versus iron sucrose in patients with iron deficiency

Journal Article

Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational

Journal Article

Aneurysmal dilatation of the aortic sinuses of Valsalva — beyond Marfan syndrome: a single centre experience

Maryanne Caruana,Mary N. Sheppard,Wei Li

Journal Article

Lung transplantation for bronchiolitis obliterans syndrome after allogenic hematopoietic stem cell transplantation

Fei Gao, Jingyu Chen, Dong Wei, Bo Wu, Min Zhou

Journal Article

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Journal Article

Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis

Jian Liu, Weiming Wang

Journal Article

Cushing’s syndrome during pregnancy caused by adrenal cortical adenoma: a case report and literature

Wei Wang,Fengyi Yuan,Dan Xu

Journal Article

Differential diagnosis of cervical nerve compression syndrome of the external intervertebral foramen

WANG Jinwu, NI Weifeng, XU Jianguang, ZHU Haibo, GUO Shangchun, ZENG Bingfang, ZHAO Binghui

Journal Article

Familial amyloid cardiomyopathy masquerading as chronic Guillain-Barre syndrome: things are not always

Die Hu, Ling Liu, Shuguang Yuan, Yuhong Yi, Daoquan Peng

Journal Article

Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns

Jaffar A. Al-Tawfiq,Ali S. Omrani,Ziad A. Memish

Journal Article